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This medical research arises from the pandemic problem of fructose in our processed food, which is the major cause of Non-alcoholic fatty liver disease (NAFLD), which accompanies the terrible scale of modern obesity. This hepatitis-related obesity carries high risks of dementia, cirrhosis, and cancer. The effects are similar to those of alcoholism, but awareness of risks is even lower. This study identifies fructose as doing its damage by causing changes to the barrier function of the intestine, which is a new understanding of how the liver-disease starts. The study proposes the idea that a genetic intervention might, at some time in the future, prevent these changes to some degree, in people very seriously affected. It points to genetic interventions in mice made ill by high fructose-induced diets. The authors of the study note that it would, of course, be better not to ingest the fructose. They do not go into the addictive nature of fructose, which helps sales-volumes and makes it very difficult for individuals to stop eating fructose-laden products. We have also embedded a video about fructose from the U of California.